Clinical Trial: Treatment of Hypertrophic Scars Using Fractional Laser and Fractional Laser-assisted Topical Corticosteroid Delivery

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Treatment of Hypertrophic Scars Using Fractional Laser and Fractional Laser-assisted Topical Corticosteroid Delivery

Brief Summary: The objective of this study is to evaluate the efficacy and safety of using ablative fractional laser- assisted topical corticosteroid delivery for the treatment of hypertrophic scar.

Detailed Summary:

Hypertrophic scars are common conditions that cause persistent symptom and can lead to severe psychosocial impairment. Intralesional corticosteroid have been a mainstay in the treatment of hypertrophic scars. However, there are many disadvantages of corticosteroid injection such as severe pain, skin atrophy, skin thinning, steroid acne, telangiectasia and hypopigmentation.

Recent reports propose new treatment methods for hypertrophic scars with the use of fractional ablative lasers to create zones of ablation of the skin that may assisted the penetration of drugs to the skin.

Sponsor: Mahidol University

Current Primary Outcome: Scar thickness measured by digital calliper [ Time Frame: change from baseline in scar thickness at 6 months ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Patient and observer scar assessment scale [ Time Frame: Baseline, 1 month after first treatment, 1,3 and 6 months after fourth treatment ]

Original Secondary Outcome: Same as current

Information By: Mahidol University

Dates:
Date Received: April 11, 2015
Date Started: April 2014
Date Completion:
Last Updated: June 30, 2015
Last Verified: June 2015