Clinical Trial: Effect of Short-term Oxygen During CPET in Pulmonary Hypertension

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Effect of Short-term Oxygen Therapy on Cardiopulmonary Exercise Capacity in Patients With Pulmonary Arterial and Chronic Thromboembolic Pulmonary Hypertension

Brief Summary: In a randomized, sham-controlled trial the investigators will test whether supplemental oxygen given during cardiopulmonary exercise testing will improve exercise performance and physiological parameters in patients with pulmonary arterial or chronic thromboembolic pulmonary hypertension.

Detailed Summary:
Sponsor: University of Zurich

Current Primary Outcome:

  • Watt [ Time Frame: 1 day ]
  • exercise time [ Time Frame: 1 day ]


Original Primary Outcome: Watt and exercise time [ Time Frame: 1 day ]

Current Secondary Outcome:

  • Peak oxygen uptake [ Time Frame: 1 day ]
  • Respiratory exchange ratio [ Time Frame: 1 day ]
  • ventilatory equivalent of carbon dioxide (VE/VCO2) slope [ Time Frame: 1 day ]
  • end-tidal pressures of carbon dioxide (PET CO2) [ Time Frame: 1 day ]
  • Changes in arterial blood parameters [ Time Frame: 1 day ]


Original Secondary Outcome:

  • Peak oxygen uptake [ Time Frame: 1 day ]
  • Respiratory exchange ratio [ Time Frame: 1 day ]
  • VE/VCO2 slope [ Time Frame: 1 day ]
  • PET CO2 [ Time Frame: 1 day ]
  • Changes in arterial blood parameters [ Time Frame: 1 day ]


Information By: University of Zurich

Dates:
Date Received: October 4, 2012
Date Started: December 2012
Date Completion:
Last Updated: August 11, 2016
Last Verified: August 2016