Clinical Trial: Pulmonary Perfusion Heterogeneity in Patients With CTEPH Using Functional PET Imaging

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Evaluation of Pulmonary Perfusion Heterogeneity in Patients With Chronic Thromboembolic Pulmonary Hypertension Using Functional PET Imaging

Brief Summary: This study with evaluate blood flow in the lungs of patients prior to and after surgery for treatment.

Detailed Summary: Specifically, we will evaluate the length-scale or size of blood flow alterations using filtering techniques with the objective of identifying the size of blood vessels that are obstructed by clot (large vessels versus small vessels).
Sponsor: Massachusetts General Hospital

Current Primary Outcome: perfusion heterogeneity [ Time Frame: 4 months ]

We will use a method to analyze the length-scale of perfusion heterogeneity before and after surgery for CTEPH. Briefly, this method consists of filtering the images with filters of different spatial size (length, mm) and measuring the coefficient of variation (CV) of perfusion in the imaged field. We then bin the CV into the following intervals: 12-36 mm, 36-60 mm, 60-84 mm, 84-108 mm and >108 mm and compare the CV in each bin among subjects.


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Massachusetts General Hospital

Dates:
Date Received: April 2, 2014
Date Started: February 2014
Date Completion:
Last Updated: March 22, 2017
Last Verified: March 2017