Clinical Trial: Gene Expression Profiles in Chronic Periodontitis

Study Status: Active, not recruiting
Recruit Status: Active, not recruiting
Study Type: Observational

Official Title: Gene Expression Profiles in Chronic Periodontitis: A Gene Network-based Microarray Analysis

Brief Summary:

Current concepts of the causes of periodontitis implicate a bacterial infection as the primary cause of the disease. Several bacterial species residing in a biofilm on tooth surfaces are closely associated with periodontitis. Chronic periodontitis (CP) is initiated and sustained by bacterial plaque, but host defense mechanisms play an integral role in its pathogenesis.

Gene expression profiling is a powerful means of generating comprehensive genome-level data sets on diseases such as cancer, asthma, rheumatoid disorders and periodontitis, and provides significant insight information for these diseases. Gene expression profiling may provide an evidence for involving genes in the pathogenesis of CP and generate further information other than clinical signs and symptoms of CP.

The aim of this study was to identify gene-expression patterns of patients with chronic periodontitis by whole-transcriptome gene-expression analyses.

Detailed Summary:
Sponsor: Kocaeli University

Current Primary Outcome: mRNA quantification [ Time Frame: 2 months ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Gen networking map [ Time Frame: 2 months ]

Original Secondary Outcome: Same as current

Information By: Kocaeli University

Dates:
Date Received: June 3, 2015
Date Started: February 2013
Date Completion: May 2017
Last Updated: August 30, 2016
Last Verified: August 2016