Clinical Trial: Serum TRAP-5b Levels in Patients With Generalized Chronic Periodontitis

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: The Effect of Non-surgical Periodontal Therapy With or Without Systemic Administration of Amoxicillin and Metronidazole on Serum Levels of TRAP-5b in Patients With Generalized Ch

Brief Summary: To compare the effect of non-surgical periodontal therapy with or without systemic administration of amoxicillin and metronidazole on the concentration of serum levels of TRAP-5b in patients with generalized chronic periodontitis.

Detailed Summary:

30 Chronic periodontitis subjects were divided into two groups- group A underwent scaling and root planing and group B underwent scaling and root planing with systemic administration of amoxicillin of 500 mg and metronidazole of 400 mg thrice daily for 7 days.

Periodontal parameters probing pocket depth and clinical attachment level were measured at baseline and at 3rd month. Serum TRAP-5b levels were also measured at baseline, 1 month and at 3rd month.

Sponsor: Meenakshi Ammal Dental College and Hospital

Current Primary Outcome: Serum levels of TRAP-5b [ Time Frame: Baseline and 3 months ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

• Probing pocket depth [ Time Frame: Baseline and 3 months ]
  Probing pocket depth was measured using Williams periodontal probe at baseline and at 3rd month
• Clinical attachment level [ Time Frame: Baseline and 3 months ]
  Clinical attachment level was measured as a distance between base of pocket and a fixed point on the crown, such as cemento-enamel junction at baseline and at 3rd month.

Original Secondary Outcome: Same as current

Information By: Meenakshi Ammal Dental College and Hospital

Dates:
Date Received: January 28, 2017
Date Started: March 1, 2016
Date Completion:
Last Updated: February 1, 2017
Last Verified: January 2017