Clinical Trial: Omega-3 Fatty Acids in Chronic Periodontitis.

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Effect of Scaling & Root Planing (SRP) Combined With Therapy Of Omega-3 Fatty Acid on Clinical Parameters and Serum Levels of C-Reactive Protein (CRP) in Chronic Periodontiti

Brief Summary: Omega 3 fatty acids is one such dietary supplement, known to modulate the host response in chronic conditions like cardiovascular diseases, rheumatoid arthritis, ischemic cerebrovascular diseases, osteoporosis by producing Resolvins and protectins without showing any inadvertent effects.Addition of systemic Omega 3 Fatty Acids with SRP may enhance the therapeutic result of Chronic Periodontitis owing to host modulation & anti-inflammatory properties. If proven, this can be used as a routine treatment modality.

Detailed Summary:
Sponsor: Tatyasaheb Kore Dental College

Current Primary Outcome:

• Change from baseline in serum CRP level at 6 weeks and 12 weeks [ Time Frame: baseline, 6 weeks, 12 weeks ]
  changes from baseline in biochemical parameter, serum CRP levels were assessed at 6 weeks and 12 weeks after starting therapy with omega 3 fatty acids. Serum CRP level was measured in milligram/liter (mg/l)
• Changes from baseline in pocket depth (PD) at 6 weeks and 12 weeks [ Time Frame: baseline, 6 weeks and 12 weeks ]
  changes from baseline in clinical parameter, PD were assessed at 6 weeks and 12 weeks after starting therapy with omega 3 fatty acids. PD was measured in millimeter.
• Changes from baseline in Clinical Attachment Level (CAL) at 6 weeks and 12 weeks. [ Time Frame: baseline, 6 weeks and 12 weeks ]
  changes from baseline in clinical parameter, CAL were assessed at 6 weeks and 12 weeks after starting therapy with omega 3 fatty acids. CAL was measured in millimeter.

Original Primary Outcome: Same as current

Current Secondary Outcome:

• Changes from baseline in Gingival Index (GI) at 6 weeks and 12 weeks [ Time Frame: baseline, 6 weeks and 12 weeks ]
  changes from baseline in standard clinical parameter, GI were assessed at 6 weeks and 12 weeks after starting therapy with omega 3 fatty acids. GI has a scoring criteria specified by Silness & Loe, 1963.
• Changes from baseline in Plaque Index (PI) at 6 weeks and 12 weeks [ Time Frame: baseline, 6 weeks and 12 weeks ]
  changes from baseline in standard clinical parameter, PI were assessed at 6 weeks and 12 weeks after starting therapy with omega 3 fatty acids. PI has a scoring criteria specified by Loe & Silness, 1964.
• Changes from baseline in Oral Hygiene Index Simplified (OHIS) at 6 weeks and 12 weeks. [ Time Frame: baseline, 6 weeks and 12 weeks ]
  changes from baseline in standard clinical parameter, OHIS were assessed at 6 weeks and 12 weeks after starting therapy with omega 3 fatty acids. OHIS has a scoring criteria specified by Greene and Vermilion, 1964.
• Changes from baseline in Sulcus Bleeding Index (SBI) at 6 weeks and 12 weeks [ Time Frame: baseline, 6 weeks and 12 weeks ]
  changes from baseline in standard clinical parameter, SBI were assessed at 6 weeks and 12 weeks after starting therapy with omega 3 fatty acids. SBI has a scoring criteria specified by Muhleman (1971).

Original Secondary Outcome: Same as current

Information By: Tatyasaheb Kore Dental College

Dates:
Date Received: November 20, 2013
Date Started: July 2012
Date Completion:
Last Updated: November 24, 2013
Last Verified: November 2013