Clinical Trial: Relationship Between Chronic Periodontitis and Vitamin D and Calcium in Men

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Relationship Between Chronic Periodontitis and Vitamin D and Calcium in Men

Brief Summary: Objective: The objective was to evaluate whether serum vitamin D and calcium concentrations are associated with chronic periodontitis in Syrian men Methods: This study designed as "Matched Case-Control Study".200 males will be enrolled in this study and will be divided into two groups. First group consist of 100 patients suffering from chronic periodontitis and no systemic diseases. Second group consist of 100 healthy volunteers. Serum vitamin D and calcium concentrations will be tested. Periodontal indexes include probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP) will be taken. Data will be collected and analyzed.

Detailed Summary:

Periodontal disease including chronic periodontitis results from interaction between pathogens and the host inflammatory response. This interaction triggers a complex process of inflammatory events, which in turn promote connective tissue destruction and alveolar bone remodeling. Periodontitis is described as a multifactorial irreversible and cumulative condition, initiated and propagated by bacteria and host factors.

Vitamin D and calcium are fundamental for bone mineralization and for the prevention of osteoporosis Severe vitamin D deficiency lead to mineralization defects but chronically low intake of vitamin D and calcium leads to bade calcium balance and bone loss, and it is reasonable to expect this effect to occur in alveolar bone as it does in other bones of the body. A study has showed a positive association between low bone mass or osteoporosis and alveolar bone loss and tooth loss.

Vitamin D serum concentrations might affect periodontal disease both through an effect on bone mineral density (BMD) and through immunomodulatory effects. Vitamin D is well established as being essential for bone growth and preservation. A potential anti-inflammatory effect of vitamin D is supported by an increasing amount of literature. The active metabolite of 25-hydroxyvitamin D, 1,25dihydroxyvitamin D, has been found to inhibit cytokine production and cell proliferation.

Low serum levels of vitamin D have been linked with a loss of periodontal attachment. Data from over 11,000 subjects were analyzed for serum vitamin D levels and attachment loss. In subjects less than 50 years of age, there was no significant association reported between vitamin D levels and attachment loss. In patients 50 years or older, serum vitamin D levels were inversely associated with attac
Sponsor: Damascus University

Current Primary Outcome:

  • Serum Vitamin D concentration [ Time Frame: One time assessment, within 24 hours before delivering any treatment ]
  • Serum Calcium concentration [ Time Frame: One time assessment, within 24 hours before delivering any treatment ]


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Pocket Depth [ Time Frame: One time assessment once sample recruitment has completed and within 24 hours before delivering any treatment. ]
  • Bleeding on Probing [ Time Frame: One time assessment once sample recruitment has completed and within 24 hours before delivering any treatment. ]
  • Clinical Attachment Loss (CAL) [ Time Frame: One time assessment once sample recruitment has completed and within 24 hours before delivering any treatment. ]


Original Secondary Outcome: Same as current

Information By: Damascus University

Dates:
Date Received: April 25, 2014
Date Started: May 2014
Date Completion:
Last Updated: October 2, 2015
Last Verified: October 2015