Clinical Trial: Study of Stored Tumor Samples in Young Patients With Brain Tumors

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Molecular and Histopathologic Characterization of Atypical Teratoid Rhabdoid Tumors, Choroid Plexus Carcinomas, Ependymomas, Medulloblastoma/PNET and Gliomas of the Pediat

Brief Summary: This laboratory study is looking at stored tumor samples in young patients with brain tumors. Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

Detailed Summary: The overall objective of this non-therapeutic protocol is to identify molecular abnormalities within prospectively treated pediatric CNS develop xenograft and in vitro models derived from Atypical Teratoid Rhabdoid Tumors (ATRT), Choroid Plexus Carcinomas (CPC), Ependymoma and high-grade gliomas. The investigators will characterize the genome-wide mutation, expression and epigenetic signatures of these models and compare them with the primary tumors from which they were derived, thus creating well-characterized and invaluable resource for research on these rare and deadly pediatric brain tumors. This will also provide important insights into intratumoral heterogeneity, and molecular abnormalities that may influence the selective pressures driving evolution, and tumor growth as xenografts or in vitro. and define the relationship between these abnormalities and tumor histologic and clinical characteristics. This objective will be achieved by applying state-of-the-art DNA, RNA and protein epigenome analysis tools to the study of fresh frozen, fixed and cultured tumor cells and xenografts. The establishment of cell cultures from each tumor sample will also allow for in vitro and in vivo analysis of tumor cell growth, signaling and therapeutic response.
Sponsor: St. Jude Children's Research Hospital

Current Primary Outcome: Relationship between molecular abnormalities and tumor histologic and clinical characteristics [ Time Frame: 20 Years ]

Original Primary Outcome: Relationship between molecular abnormalities and tumor histologic and clinical characteristics

Current Secondary Outcome:

Original Secondary Outcome:

Information By: St. Jude Children's Research Hospital

Dates:
Date Received: May 9, 2009
Date Started: November 30, 2004
Date Completion: February 28, 2026
Last Updated: March 31, 2017
Last Verified: August 2016