Clinical Trial: Chorioamnionitis and Proinflammatory S100A12

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Impact of Chorioamnionitis on Maternal and Fetal Levels of Proinflammatory S100A12

Brief Summary: Histologic chorioamnionitis (HCA) may lead to the fetal inflammatory response syndrome (FIRS) and increased levels of proinflammatory molecules.

Detailed Summary:

Histologic chorioamnionitis (HCA) may lead to the fetal inflammatory response syndrome (FIRS). The aim of this pilot study was to evaluate S100A12, a marker of innate immune activation, in mothers with or without HCA and in their infants.

Concentrations of S100A12, Interleukin 6 (IL-6) and C-reactive protein (CRP) were evaluated in maternal, cord, and neonatal blood of very preterm infants. Histologic examinations of placentae and umbilical cords were performed.


Sponsor: Catholic University of the Sacred Heart

Current Primary Outcome: S100A12 in Presence of Maternal Chorioamnionitis [ Time Frame: 1 Year ]

Levels of S100A12 in Maternal, Cord and Neonatal Blood in the Presence or Absence of HCA


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Catholic University of the Sacred Heart

Dates:
Date Received: November 25, 2016
Date Started: February 2012
Date Completion:
Last Updated: December 14, 2016
Last Verified: December 2016