Clinical Trial: Role of ASICs in Human Inflammatory Pain

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Study of the Role of Acid Sensing Ion Channels (ASICs) in Human Inflammatory Pain

Brief Summary: In recent years, ion channels have emerged as new therapeutic targets for pain. Among these channels, ASICs (Acid Sensing Ion Channels) are of particular interest because they are directly activated by extracellular acidity, which is a major cause of pain. Indeed, many painful conditions such as ischemia, inflammation, tumor development or tissue incision are accompanied by tissue acidification. ASIC are excitatory ion channels that are expressed in neurons, including nociceptive sensory neurons. In humans, the use of amiloride, a nonspecific inhibitor of ASICs, has demonstrated their role in the perception of pain induced by subcutaneous injections of acidic solutions. ASICs thus appear as new candidates capable of mediating pain in humans. A growing number of data suggests that, in addition to protons, ASICs may also be activated by one or more endogenous compounds produced during inflammation. The purpose of this research project is to identify these compounds by testing the effects of human inflammatory exudates on ASICs activity. The discovery of such compounds would definitely validate ASICs as novel therapeutic targets for pain treatment in humans

Detailed Summary:
Sponsor: Centre Hospitalier Universitaire de Nice

Current Primary Outcome: activation or miodulation to Electrical potential of ionic channel in the synovial fluid [ Time Frame: 1 day ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Centre Hospitalier Universitaire de Nice

Dates:
Date Received: May 15, 2013
Date Started: November 2012
Date Completion: December 2018
Last Updated: October 20, 2016
Last Verified: October 2016