Clinical Trial: Results of Bile and Blood Culture in Patients With Acute Cholangitis

Study Status: Terminated
Recruit Status: Terminated
Study Type: Observational

Official Title: A Comparison of Results With Bile and Blood Culture in Patients With Acute Cholangitis According to Severity

Brief Summary:

Cholangitis is a complication of biliary statsis. Bile juice is sterile when there is no obstruction, however, it can be infected with bacteria when there is a stasis or obstruction. After infection, cholangitis can be developed because of systematic endotoxemia or bacteremia. Though identification of bacteria is very important for selection of adequate antibiotics, treatment with empirical antibiotics is commonly performed when identification of bacteria is not possible.

Identification of bacteria is usually done with blood or bile culture. In the previous studies, the same results from blood and bile were common in patients with cholangitis. However, the data of these studies were based on the bile juice which was aspirated by surgery. Considering that bile duct obstruction is usually treated with endoscopy or radiological intervention without surgery, it is necessary to collect data with endoscopic or radiologic intervention. In addition, the concordant rate of these two tests has not been reported according to severity of cholangitis. As a result, the necessities of bile and blood culture are not agreed among experts in this fields.

Our hypothesis is that concordant rates of bile and blood culture are same in patients with each moderate or severe cholangitis. However, the concordant rates of bile and blood culture are different between patients with moderate and severe cholangitis. This study will assess the positive rates of blood and bile culture in patients with moderate or severe cholangitis, respectively and compare the results according to the different severity.


Detailed Summary:
Sponsor: Seoul National University Hospital

Current Primary Outcome: Postive culture rates of blood and bile juice [ Time Frame: 1 week after culture test ]

Cultures results of blood and bile juice in patients with cholangitis are usually reported within 1 week after test in our hospital. After the completion of study, we will analyze the positive culture rates in each samples and compate those each other. In addition, we will compare the results according to the severity of cholangitis.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Identification of bacterial species in blood and bile cultures [ Time Frame: 1 week after culture test ]
    Cultures results of blood and bile juice in patients with cholangitis are usually reported within 1 week after test in our hospital. After the completion of study, we will analyze the bacterial species in each samples and compate those each other.
  • Identification of antibiotics sensitive and resistant bacterial species [ Time Frame: 1 week after culture test ]
    Cultures results of blood and bile juice in patients with cholangitis are usually reported within 1 week after test in our hospital. After the completion of study, we will analyze the antibiotics sensitive and resistant bacterial species in each samples and compate those each other.
  • Identification of colonized bacterial species [ Time Frame: 1 week after culture test ]
    Cultures results of blood and bile juice in patients with cholangitis are usually reported within 1 week after test in our hospital. After the completion of study, we will analyze the colonized bacterial species which is not true pathogens in each samples and compate those each other.


Original Secondary Outcome: Same as current

Information By: Seoul National University Hospital

Dates:
Date Received: April 3, 2014
Date Started: April 2014
Date Completion:
Last Updated: May 23, 2016
Last Verified: April 2014