Clinical Trial: Genomic Changes in Childhood Acute Lymphoblastic Leukemia

Study Status: Completed
Recruit Status: Unknown status
Study Type: Observational

Official Title: Genomics Evolution in Childhood Acute Lymphoblastic Leukemia

Brief Summary: To study the genomics with cell cycle and lymphocyte differentiation in disease, remission and relapse of childhood acute lymphoblastic leukemia. Then correlate these data with age, white cell count, cytogenetic changes, response to the chemotherapy and prognosis.

Detailed Summary: In order to know the genomic evolution of childhood acute lymphoblastic leukemia, we will collect bone marrow (10c.c.) at diagnosis, remission and relapse. We will do the following genes in addition to gene-chip including IKZF1,ETV6, EBF1, NR3C1, RAG1/G2, TCF3, BTLA, PAX5,LEF1, ERG and VPREB1.We will study the gene dosages and degree of methylation. The estimated patients numbers will be 300-400. Then we will correlate these data with patients'age, white blood cell count at diagnosis, cytogenetic abnormalities, response to the chemotherapy and prognosis.
Sponsor: National Taiwan University Hospital

Current Primary Outcome:

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Original Secondary Outcome:

Information By: National Taiwan University Hospital

Dates:
Date Received: March 17, 2010
Date Started: April 2010
Date Completion: June 2013
Last Updated: March 18, 2010
Last Verified: March 2010