Clinical Trial: A Study of the Use of Combination of Anti-cholinergic and Minor Tranquilliser in the Treatment of Non-cardiac Chest Pain - a Double Blind Placebo Controlled Study
Study Status: Recruiting
Recruit Status: Unknown status
Study Type: Interventional
Official Title: A Study of the Use of Combination of Anti-cholinergic and Minor Tranquilliser in the Treatment of Non-cardiac Chest Pain - a Double Blind Placebo Controlled Study
Brief Summary: Non-cardiac chest pain is a common clinical problem encountered in our practice but at present, the results of treatments are unsatisfactory. The pathogenesis remains unknown but altered motility of the esophagus and psychological factors including anxiety have been implicated as important factors. Reports of the single use of anticholinergic drugs and anxiolytics have yielded conflicting results, has been demonstrated to yield marginal or of no value. However the use of the combination therapy, especially with a double blind fashion have not been reported. On that basis, we propose to use a combination of anti-cholinergic and tranquilliser for the symptomatic treatment of non-cardiac chest pain. The aim of this study is to evaluate the efficacy of combination therapy of anti-cholinergic and anxiolytic drugs in the treatment of non-cardiac chest pain.
Detailed Summary:
Sponsor: Hospital Authority, Hong Kong
Current Primary Outcome: Symptoms scores, quality of life [ Time Frame: 12 Weeks ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Compliance [ Time Frame: 12 Weeks ]
- Adverse effects [ Time Frame: 12 Weeks ]
Original Secondary Outcome: Same as current
Information By: Hospital Authority, Hong Kong
Dates:
Date Received: August 15, 2007
Date Started: June 2002
Date Completion: December 2008
Last Updated: July 6, 2010
Last Verified: July 2010
