Clinical Trial: Comparison of Multifocal Electroretinogram Assessment in Chronic Central Serous Chorioretinopathy (CSC) Between Laser Treatment Group and Photodynamic Therapy Group in Chronic Central Serous Chorioretinopathy

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Comparison of Multifocal Electroretinogram Assessment Between Laser Treatment Group and Photodynamic Therapy Group in Chronic Central Serous Chorioretinopathy

Brief Summary: This study is a comparison of multifocal electroretinogram assessment between the laser treatment group and the photodynamic therapy group in chronic central serous chorioretinopathy.

Detailed Summary:

  1. Laser Group: extrafoveal focal leakage on FAG
  2. PDT Group: no definite focal leak on FAG subfoveal or juxtafoveal focal leakage on FAG, or serous retinal pigmentary epithelial detachment involving foveal center

Inclusion criteria

  1. Chronic serous chorioretinopathy (over 3 months) when subretinal fluid persisted in the subfoveal region demonstrated by clinical examination and OCT
  2. Ability to maintain steady fixation for mfERG
  3. Presence of abnormal dilated choroidal vasculature in ICGA
  4. Symptom duration over 3 months

Exclusion criteria

  1. previous PDT or laser treatment history
  2. evidence of Choriinal neovascularization in FAG
  3. other chorioretinal disorders that can cause macular exudation such as age-related macular degeneration, pathologic myopia, angioid streaks, trauma, inflammatory diseases, retinal vasculopathies, and hereditary dystrophies

follow-up Visit

1)baseline 2)1month 3)3months 4)6 months

each visit: multifocal electroretinogram, visual acuity, optical coference timography should be measured.


Sponsor: Samsung Medical Center

Current Primary Outcome: Multifocal Electroretinogram Amplitudes [ Time Frame: baseline, 1 month, 3 months, 6 months ]

Original Primary Outcome: Multifocal Electroretinogram Amplitudes [ Time Frame: baseline, 1 month, 3 months 6 months ]

Current Secondary Outcome: Best Corrected Visual Acuity [ Time Frame: baseline, 1 month, 3 months, 6 months ]

Original Secondary Outcome: Same as current

Information By: Samsung Medical Center

Dates:
Date Received: November 12, 2008
Date Started: March 2008
Date Completion:
Last Updated: March 11, 2009
Last Verified: February 2009