Clinical Trial: Chemotherapy Plus Reduced Radiotherapy in Intracranial Germinoma

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Treatment of Intracranial Germinoma With Chemotherapy Prior to Reduced Dose and Volume of Radiotherapy

Brief Summary: The purpose of this study is to evaluate the outcome of intracranial germinoma treated with chemotherapy plus reduced radiotherapy.

Detailed Summary: Treatment outcome of intracranial germinoma is excellent with radiotherapy/chemotherapy. However, late sequelae are unavoidable especially with craniospinal irradiation, and various efforts have been done to reduce the dose and extent of radiotherapy. In this study, chemotherapy and further reduced dose of radiotherapy will be used to minimize the late sequelae in the patients with intracranial germinoma.
Sponsor: Samsung Medical Center

Current Primary Outcome: Rate of late sequelae [ Time Frame: Up to 5 years ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Rate of event free survival [ Time Frame: Up to 5 years ]

Original Secondary Outcome: Same as current

Information By: Samsung Medical Center

Dates:
Date Received: May 23, 2016
Date Started: January 2013
Date Completion:
Last Updated: May 23, 2016
Last Verified: May 2016