Clinical Trial: Vitamin d Levels in Children With Bacterial Meningitis
Study Status: Recruiting
Recruit Status: Unknown status
Study Type: Observational
Official Title: Association of Serum 25-hydroxyvitamin D Levels and Outcomes in Children With Bacterial Meningitis
Brief Summary: The purpose of this study is to determine whether deficiency of Vitamin D has association with outcomes of children with bacterial meningitis.
Detailed Summary:
Vitamin D deficiency has been proved in serious diseases patients, including patients in shock, however, few study have been done about association between deficiency of Vitamin D and outcomes of children with bacterial meningitis.
in our study, we will observe incidence of complication and severity of complication between patients who have different Vitamin D status.
Sponsor: Gang Liu
Current Primary Outcome: vitamin d level change [ Time Frame: change in serum vitamin d level from baseline to 28 days after initial hospitalization ]
Original Primary Outcome: Same as current
Current Secondary Outcome:
- Clinical assessment of disease severity with Glasgow score [ Time Frame: 1 day ]Disease severity will be assessed with Glasgow score in the first day of hospitalization
- Clinical assessment of disease severity with Glasgow score [ Time Frame: 7 day ]Disease severity will be assessed with Glasgow score in the seventh day of hospitalization
- Clinical assessment of disease severity with Glasgow score [ Time Frame: 28 day ]Disease severity will be assessed with Glasgow score in the twenty-eighth day of hospitalization
- Clinical assessment of disease severity with pediatric critical illness score [ Time Frame: 1 day ]Disease severity will be assessed with pediatric critical illness score in the first day of hospitalization
- Clinical assessment of disease severity with pediatric critical illness score [ Time Frame: 7 day ]Disease severity will be assessed with pediatric critical illness score in the seventh day of hospitalization
- Clinical assessment of disease severity with pediatric critical illness score [ Time Frame: 28 day ]Disease severity will be assessed with pediatric critical illness score in the twenty-eighth day of hospitalization
- Clinical assessment of disease severity with cerebrospinal fluid examination [ Time Frame: 1 day ]Cerebrospinal fluid examination including white blood cell count, protein concentration and glucose concentration in cerebrospinal fluid
- Clinical assessment of disease severity with cerebrospinal fluid examination [ Time Frame: 7 day ]Cerebrospinal fluid examination including white blood cell count, protein concentration and glucose concentration in cerebrospinal fluid
- Clinical assessment of disease severity with cerebrospinal fluid examination [ Time Frame: 28 day ]Cerebrospinal fluid examination including white blood cell count, protein concentration and glucose concentration in cerebrospinal fluid
- Assessment of complications [ Time Frame: 1 day ]Assessment of complications include whether patients have complications, which kind of complication patients suffered, and whether needing surgical therapy.
- Assessment of complications [ Time Frame: 7 day ]Assessment of complications include whether patients have complications, which kind of complication patients suffered, and whether needing surgical therapy.
- Assessment of complications [ Time Frame: 28 day ]Assessment of complications include whether patients have complications, which kind of complication patients suffered, and whether needing surgical therapy.
Original Secondary Outcome: Same as current
Information By: Beijing Children's Hospital
Dates:
Date Received: March 18, 2015
Date Started: May 2015
Date Completion: June 2016
Last Updated: June 5, 2015
Last Verified: May 2015