Clinical Trial: Biomarkers in Tissue Samples From Young Patients With Liver Cancer
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: Genetics and Biology of Liver Tumorigenesis in Children
Brief Summary: This research trial is studying biomarkers in tissue samples from young patients with liver cancer. Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
Detailed Summary:
PRIMARY OBJECTIVES:
I. To identify biomarker signatures associated with hepatoblastoma subtypes (by microRNA array profiling), and their potential correlation with liver developmental stages as well as outcome.
II. To correlate expression array data with copy number array data.
SECONDARY OBJECTIVES:
I. To carry out a focused sequencing interrogation of amplified or deleted genomic regions as well as genes in key cell pathways involved in embryonic development and/or stem cell signaling pathways for which preliminary data suggests involvement in the pathogenesis of hepatoblastoma.
II. To perform whole exome sequencing in a subset of tumors.
OUTLINE: This is a multicenter study.
Archived tumor tissue samples are analyzed for hepatoblastoma and other liver tumor biomarkers by microRNA array profiling and exome sequencing. Results are then compared with patients' clinical data.
Sponsor: Children's Oncology Group
Current Primary Outcome: Biomarkers associated with hepatoblastoma subtypes and cancer stages [ Time Frame: Baseline ]
Original Primary Outcome: Biomarkers associated with hepatoblastoma subtypes and cancer stages
Current Secondary Outcome:
- Genes involved in embryonic development and/or stem cell signaling pathways for which preliminary data suggests involvement in the pathogenesis of hepatoblastoma [ Time Frame: Baseline ]
- Exome sequencing [ Time Frame: Baseline ]
Original Secondary Outcome:
- Genes involved in embryonic development and/or stem cell signaling pathways for which preliminary data suggests involvement in the pathogenesis of hepatoblastoma
- Exome sequencing
Information By: Children's Oncology Group
Dates:
Date Received: April 15, 2011
Date Started: April 2011
Date Completion:
Last Updated: May 17, 2016
Last Verified: May 2016