Clinical Trial: Heparin Versus Saline in Peripheral Venous Catheter

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: A Randomized Study to Test Peripheral Venous Catheter Lock Therapy With Either Heparin or Saline in Patients Admitted to the Internal Medicine Department

Brief Summary: A clinical, prospective. controlled and randomized study with patients with a peripheral venous catheter. Patients will be randomized to either receive heparin or saline. The investigators will monitored the clinical out come to further evaluate catheter colonization rate, phlebitis rate, days of hospital stay, antimicrobial costs, and adverse effects.

Detailed Summary:

The need of use of peripheral venous catheters and the importance of a proper management to avoid catheter colonization or phlebitis requires two possible preventive approaches: lock therapy with heparin or saline.

Heparin demonstrated its efficacy in central venous catheters, but there are still controversies of whether it is useful in peripheral venous catheters.

Objectives To compare the efficacy of heparin in peripheral venous catheters lock versus saline for the prevention of colonization and phlebitis in patients admitted to an Internal Medicine Department.

Methods: A clinical, prospective. controlled and randomized study with patients with a peripheral venous catheter.

Patients will be randomized to either receive heparin or saline. The investigators will monitored the clinical out come to further evaluate catheter colonization rate, phlebitis rate, days of hospital stay, antimicrobial costs, and adverse effects.


Sponsor: Hospital General Universitario Gregorio Marañon

Current Primary Outcome: complications [ Time Frame: Daily from catheter insertion until catheter withdraw(estimated 10 days) ]

prevention of colonization(superficial and tip culture) and phlebitis(visual inflammation of entrance of catheter insertion) .


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • catheter related infection rate [ Time Frame: Through study completion( estimated 2 year after Last patient in) ]
    episodes of catheter related infection against number of days of exposure to catheter
  • adverse events(number of catheter obstructions and coagulation alterations) [ Time Frame: Through study completion (2 year afterLast patient in) ]


Original Secondary Outcome: Same as current

Information By: Hospital General Universitario Gregorio Marañon

Dates:
Date Received: October 15, 2015
Date Started: October 2015
Date Completion: November 2017
Last Updated: November 21, 2016
Last Verified: November 2016