Clinical Trial: Anatomical and Structural Connectivity in Two Psychotic Phenotypes : Periodic Catatonia and Cataphasia

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Anatomical and Structural Connectivity in Schizophrenias

Brief Summary:

The different subtypes of Schizophrenia might have a disordered connectivity as their final common pathways.

The investigators will use multimodal structural MRI to assess anatomical connectivity on the one side and its functional consequence on functional connectivity on the other side to assess two phenotypes of psychosis : periodic catatonia and cataphasia in comparison with control subjects.

The coherence between structural and functional anomalies will be especially studied.


Detailed Summary:
Sponsor: University Hospital, Strasbourg, France

Current Primary Outcome: Changes in structural and functional connectivity according to the phenotype. Correlation between these changes [ Time Frame: Subjects will be assessed only once. ]

Statistical parametric mapping (SPM) will be applied on quantitative maps : rCBF (ml/100g/min), susceptibility (part per billion), R1, R2, R2* (all expressed in ms-1), fractional anisotropy (fraction), averaged diffusivity (μm²/sec), macromolecular proton fraction (percentage), cortical thickness (mm), VBM (probability of grey and white matter) and contrast maps (BOLD signal correlation with the anterior cingulate ROI).


Original Primary Outcome: Same as current

Current Secondary Outcome: Changes in rCBF and cognition according to the phenotype. Correlation between the different changes and the symptomatic scales. [ Time Frame: Subjects will be assessed only once. ]

Symptomatic scales : PANSS, SANS, SAPS, Calgary, Bush and Francis catatonia scale, the psychological experimental test operationalized for cataphasia, Clinician-rated dimension of psychosis symptom severity questionnaire assessing handedness, anhedonia, vigilance, QoL, activity, handicap, ruminations, depression and personality.

Cognitive tests : grammar tests, semantic priming, implicit memory, CPT, fNART, Mill-Hill (part B)



Original Secondary Outcome: Same as current

Information By: University Hospital, Strasbourg, France

Dates:
Date Received: August 5, 2016
Date Started: December 2006
Date Completion: December 2017
Last Updated: November 4, 2016
Last Verified: November 2016