Clinical Trial: Mesenchymal Stem Cells in Knee Cartilage Injuries

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Use of Mesenchymal Stem Cells for the Repair of Articular Cartilage Disorder of Knee Using Intra-articular Injection of Mesenchymal Cells Alone or Mesenchymal Cells With P

Brief Summary: Induction of autologous repair chondrogenesis to regenerate injured articular cartilage using bone marrow mesenchymal stem cells (MSCs) after in vitro expansion under restricted culturing conditions.

Detailed Summary:

Fourteen patients from both genders, age range 40-68, will be enrolled according to strict inclusion and exclusion criteria, divided into two equal groups based upon receiving autologous MSCs alone, or MSCs supported by platelet lysate through percutaneous injection.

The patients are followed by clinical assessment, laboratory investigations as well as magnetic resonance imaging (MRI) of the injected knee.

The investigators hypothesize that the two groups will give satisfactory clinical outcomes, but the investigators are looking forward to assessing the best product that will activate chondrogenesis and heal cartilaginous injury.


Sponsor: University of Jordan

Current Primary Outcome: Assessing the therapeutic benefits of the injected Autologous Mesenchymal Stem Cells. [ Time Frame: 12 months ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Assessment of the articular cartilage healing in osteoarthritic patients through intra articular injection of Autologus Mesenchymal stem cell with/or without supported product. [ Time Frame: 12 months ]

For every patient tests would be performed repeated at 6, and 12 months post-injection.


Original Secondary Outcome: Same as current

Information By: University of Jordan

Dates:
Date Received: January 24, 2014
Date Started: January 2014
Date Completion:
Last Updated: February 23, 2016
Last Verified: February 2016