Clinical Trial: Effect of Autologous Peripheral Blood Stem Cell Treatment on Articular Cartilage Regeneration

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Articular Cartilage Regeneration With Autologous Peripheral Blood Stem Cells Versus Hyaluronic Acid: A Randomized, Controlled Trial

Brief Summary: The purpose of this study was to compare histologic and MRI evaluation of articular cartilage regeneration in patients with chondral lesions treated by arthroscopic subchondral drilling followed by postoperative intra-articular injections of hyaluronic acid (HA) with and without peripheral blood stem cells (PBSC)

Detailed Summary: The purpose of this study was to compare histologic and magnetic resonance imaging (MRI) evaluation of articular cartilage regeneration in patients with chondral lesions treated by arthroscopic subchondral drilling followed by postoperative intra-articular injections of hyaluronic acid (HA) with and without peripheral blood stem cells (PBSC)
Sponsor: Kuala Lumpur Sports Medicine Centre

Current Primary Outcome: Change in tissue histology after subchondral drilling surgery using serial MRI scanning and cartilage biopsies [ Time Frame: 18 months ]

Original Primary Outcome: Improved long term functional outcome of microfracture surgery in the knee joint [ Time Frame: 18 months ]

Current Secondary Outcome: Improved long term functional outcome of subchondral drilling surgery in the knee joint [ Time Frame: 18 months ]

Original Secondary Outcome: Change in morphology after microfracture surgery using MRI scanning and to verify this histologically with cartilage biopsies taken during second look arthroscopy [ Time Frame: 18 months ]

Information By: Kuala Lumpur Sports Medicine Centre

Dates:
Date Received: February 24, 2010
Date Started: October 2009
Date Completion:
Last Updated: March 12, 2015
Last Verified: March 2015