Clinical Trial: Early Detection of Cardiac Toxicity in Childhood Cancer Survivors

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Early Detection of Cardiac Toxicity in Childhood Cancer Survivors

Brief Summary: To evaluate cardiac MRI and/or serum biomarkers for detecting cardiac cardiac toxicity in children who received anthracycline based chemotherapy (ABC).

Detailed Summary: Cardiac toxicity is a significant potential complication for patients receiving anthracycline chemotherapy. Cells in the cardiovascular system have limited regenerative capability, making them susceptible to long term adverse effects from these chemotherapeutic agents. The ability to detect subclinical changes in cardiac function will allow clinicians to use proven treatments to prevent further progression in this vulnerable population. The current standard testing uses echocardiography, which is not as sensitive as cardiac MRI or serum biomarkers.
Sponsor: Niti Dham

Current Primary Outcome: Echocardiogram marker measurements pre ABC chemo and post ABC [ Time Frame: At the end of each cardiac MRI exam through study completion, up to 5 years ]

•Measure echocardiogram markers on pre anthracycline based chemotherapy (ABC) and post ABC echocardiograms, using standard echocardiogram measurements and speckle tracking.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Detection of cardiac toxicity on MRI and echocardiogram [ Time Frame: At the end of each cardiac MRI exam through study completion, up to 5 years ]
    •Measure sensitivity of detecting cardiac toxicity between standard echocardiogram, speckle tracking on echo, and MRI
  • Serum biomarkers correlation [ Time Frame: At the end of the study, up to 10 years ]
    •Correlate measurement of serum biomarkers with prevalence of cardiac changes measured on echocardiograms and MRI imaging.


Original Secondary Outcome: Same as current

Information By: Children's Research Institute

Dates:
Date Received: January 30, 2017
Date Started: November 2014
Date Completion: December 2020
Last Updated: February 3, 2017
Last Verified: February 2017