Clinical Trial: Validation of Capnography as a Predictor of Cardiac Output Change as Measured by FloTrac

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Validation of Capnography as a Predictor of Cardiac Output Change as Measured by FloTrac

Brief Summary:

The aim of this study is to evaluate the correlation of capnography with non-invasive measurement of cardiac output with the FloTrac/EV1000 following a reversible fluid challenge, a passive leg raising maneuver, using thermodilution as the gold standard.

The main hypothesis is a correlation of 0.8 between the increasing of ETCO2 and the increasing of ejection volume measured by FloTrac/EV1000 following a passive leg raising maneuver.


Detailed Summary:

Data are collected on past medical illnesses, medication, type of surgery, abnormalities on pre-operative transesophageal echocardiogram and localisation of arterial line.

Before induction of anesthesia, an arterial line is installed. The agents of induction of anesthesia and doses are left to the discretion of the attending anesthesiologist. The trachea is intubated, anesthesia circuit and sidestream CO2 sensor were connected to the endotracheal tube and positive pressure ventilation begins with standardized parameters: control assisted mode with no inspiratory effort, tidal volume of 6-8 mL/kg, respiratory rate of 8-10/minute and PEEP of 5 mmHg. Modification of the ventilation parameters is not permitted before and during the PLR maneuvers. Isoflurane and propofol are used for the maintenance of anesthesia. A PA catheter (Paceport, Edwards Lifesciences, Irvine, California, USA) is inserted in the right internal jugular vein. If a femoral line is installed, the FloTrac/EV1000 is connected to the femoral line, if not, the radial line is used for mini-invasive continuous cardiac output monitoring. The a and v wave aspect and ratio of CVP waveform is noted. The RV waveform is inspected for signs of abnormalities such as a non-horizontal slope restrictive pattern (Figure xx)18. The transducers are all placed at the midthoracic level and a "flush test" is performed prior to CO measurements with the FloTrac/EV1000 to ensure absence of resonance or damping of the system.

At baseline, in the operating room before the first PLR maneuver, the heart rate, systolic, diastolic and mean arterial pressure, CVP value, CI measured in triplicate with the thermodilution method and the FloTrac derived variables are recorded. These variables include the CO indexed CO and SVV measured by the FloTrac/EV1000. The same variables are rec
Sponsor: Montreal Heart Institute

Current Primary Outcome: Correlation between elevation in ETCO2 and cardiac output during a reversible fluid challenge, a passive leg raise [ Time Frame: Participants will be followed from their arrival in the operating room until 2 hours post-operatively in the intensive care unit ]

Correlation of 0.8 between the increase of ETCO2 and the increase of ejection volume measured by FloTrac/EV1000 following a passive leg raising maneuver


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Correlation between changes in indexed cardiac output measured by Flotrac/EV1000 and by thermodilution during a reversible fluid challenge, a passive leg raise [ Time Frame: Participants will be followed from their arrival in the operating room until 2 hours post-operatively in the intensive care unit ]
  • Correlation between elevation in capnography and indexed cardiac output measured by thermodilution during a reversible fluid challenge, a passive leg raise [ Time Frame: Participants will be followed from their arrival in the operating room until 2 hours post-operatively in the intensive care unit ]
  • Correlation between changes in capnography and indexed cardiac output measured by Flotrac/EV1000 during a reversible fluid challenge, a passive leg raise [ Time Frame: Participants will be followed from their arrival in the operating room until 2 hours post-operatively in the intensive care unit ]


Original Secondary Outcome: Same as current

Information By: Montreal Heart Institute

Dates:
Date Received: June 7, 2013
Date Started: March 2013
Date Completion:
Last Updated: April 3, 2014
Last Verified: April 2014