Clinical Trial: Oral Candida in Infants and Dietary Type

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Evaluation the Effect of Dietary Type on Oral Candida Carriage in Infants

Brief Summary: This is an observational, non-randomised trial to evaluate the effect of dietary type on infants oral candida colonization the investigators evaluated 90 infants in 1-24 months (45 breastfeeding and 45 bottle feeding infants) who attended to Yazd clinic for regular pediatric appointment. Infants with unremarkable health histories, normal weight, free of sign or symptom of oral candidiasis or other mucosal disease. Their mothers were also healthy and without sign or symptom of vagina or mammary candidiasis. Pacifier usage, use of antibiotics in last months, sign or symptom of oral candidiasis in infants or vagina and mammary candidiasis in mothers were exclusion criteria.

Detailed Summary: After filling in a questionnaire about infants dietary intake, age and sex and their mothers education level and health condition, a pre-moistened sterile cotton swab was taken from dorsal surface of tongue and mid-plate. The swabs were cultured in agar plate containing sabourauds dextrose agar medium with chloramphenicol, and kept in 37 C for 48 hours. The number of candida colonies was counted and germ tube test performed to separate candida albicans from other types. The data was collected and analyzed by SPSS software and chi-square, logistic regression and mann-whitney test. Study hypothesis: feeding by mothers milk reduces oral candida colonization.
Sponsor: Shahid Sadoughi University of Medical Sciences and Health Services

Current Primary Outcome: mean number of candida colonies [ Time Frame: 6 months ]

number of candida colonies growth in agar plate


Original Primary Outcome: Same as current

Current Secondary Outcome: prevalence of oral candida colonization in infants according to age and sex [ Time Frame: 6 months ]

exist of candida colony in agar plate


Original Secondary Outcome: Same as current

Information By: Shahid Sadoughi University of Medical Sciences and Health Services

Dates:
Date Received: September 18, 2011
Date Started: July 2009
Date Completion:
Last Updated: September 21, 2011
Last Verified: September 2011