Clinical Trial: Evaluate the Performance of Genetic Amplification by Polymerase Chain Reaction (PCR) and the "Mannan Antigenemia and Antimannan Antibodies Couple as a Means of Diagnosis and a Marker of Follow-up in Invasive Candidiasis.

Study Status: Completed
Recruit Status: Unknown status
Study Type: Observational

Official Title: Diagnostic Value of PCR Genetic Amplification and Mannan Antigenemia Coupled With Antimannan Antibodies in Intensive Care Patients With Suspected Invasive Candidiasis

Brief Summary:

The study consists in taking 4 tubes of blood at different times over a period of 10 days, via a catheter (central venous or arterial catheter) already in place in the usual therapeutic management. These samples will make it possible to measure blood levels of certain markers specific to invasive candidiasis. PCR will be used to quantify fungal load precisely, that is to say the quantity of yeast present in the blood and to monitor this quantity over time.

These samples will be transferred to a specialized unit and stored for a maximum of three years for use at the end of the study.

Detailed Summary:
Sponsor: Centre Hospitalier Universitaire Dijon

Current Primary Outcome: Change from the start of treatment in genomic DNA of Candida sp. by quantitative PCR [ Time Frame: At day 1, day 3, day 5, Day 7 and Day 10 after the start of antifungal treatment with echinocandin. ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Change from the start of treatment in mannan antigenemia and antimannan antibodies [ Time Frame: At day 1, day 5 and day 10 after the start of treatment ]

Original Secondary Outcome: Same as current

Information By: Centre Hospitalier Universitaire Dijon

Dates:
Date Received: December 5, 2014
Date Started: October 2014
Date Completion:
Last Updated: January 5, 2015
Last Verified: October 2014