Clinical Trial: Evaluation of the Signaling Path of Emiline1-TGFβ in the Myogenic Tone of Resistance Arteries in a Population of Normotensive and Hypertensive Subjects

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Evaluation of the Signaling Path of Emiline1-TGFβ in the Myogenic Tone of Resistance Arteries in a Population of Normotensive and Hypertensive Subjects

Brief Summary: Aim of this study is to enhance the knowledge of myogenic tone alterations in hypertensive patients and to better understand the mechanisms controlling the myogenic tone. Evaluations will be performed through ex vivo studies of peripheral arterioles in human adipose tissue from lumbar muscle, isolated from biopsies. This will allow investigators to evaluate the myogenic function in response to progressive blood pressure increases, in order to correlate myogenic function to arterial hypertension and to the molecular mechanisms already identified in the preclinical models.

Detailed Summary:
Sponsor: Neuromed IRCCS

Current Primary Outcome: Myogenic tone measured by micromyographic technique to evaluate small-artery morphology. [ Time Frame: 12 months ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Neuromed IRCCS

Dates:
Date Received: November 28, 2014
Date Started: January 2015
Date Completion:
Last Updated: March 13, 2017
Last Verified: March 2017