Clinical Trial: Intravenous Sodium Thiosulfate on Coronary Calcification in Patients on Hemodialysis
Study Status: Completed
Recruit Status: Completed
Study Type: Interventional
Official Title: The Treatment Effect of Intravenous Sodium Thiosulfate on Coronary Calcification in Patients on Hemodialysis
Brief Summary: The present study will examine the treatment effect of sodium thiosulfate on coronary calcification in patients on hemodialysis.
Detailed Summary: Coronary calcification (CAC) is prevalent among patients with end-stage renal disease (ESRD). High serum phosphate, the intake of calcium containing phosphate binder as well as dialysis vintage have been shown to be associated with the increasing prevalence of CAC. High CAC score examined by electron-beam CT scan or multi-slice CT scan associates with an increased cardiovascular mortality in ESRD. In series of case reports, intravenous sodium thiosulfate (STS) reduced the calcium burden in calcific uremic arteriopathy and soft tissue calcification. This was believed to be due to the calcium chelation effect of STS.
Sponsor: Ramathibodi Hospital
Current Primary Outcome: CAC score [ Time Frame: 6 months ]
Original Primary Outcome: Same as current
Current Secondary Outcome: Bone mineral density, calcium removal [ Time Frame: 6 months, 1 and 2 months ]
Original Secondary Outcome: Same as current
Information By: Ramathibodi Hospital
Dates:
Date Received: July 21, 2008
Date Started: July 2008
Date Completion:
Last Updated: December 16, 2009
Last Verified: December 2009