Clinical Trial: Polyethylene-glycol Assisted Nerve Repair in Phalloplasty
Study Status: RECRUITING
Recruit Status: RECRUITING
Study Type: INTERVENTIONAL
Official Title: Nerve Repair Using Hydrophilic Polymers to Improve Tactile and Erogenous Neophallus Sensation
Brief Summary: Phalloplasty, a genitourinary surgery for transmasculine patients, reconstructs a neophallus using tissue transferred from other parts of the body to the groin.
However, this technique fails to provide adequate sensation, causing regret and persistent dysphoria.
Peripheral nerve regeneration is the greatest barrier to sensory recovery, given the slow rate of regrowth coupled with the negative effects of axonal degeneration.
Topical application of polyethylene glycol (PEG) fuses severed axonal membranes, restoring the nerve's immediate ability to conduct electrical signals across the repair site.
We hypothesize that utilizing PEG in phalloplasties will significantly improve neophallus sensation and postoperative quality of life.
Detailed Summary:
With more than 1.6 million transgender and nonbinary (TGNB) individuals in the United States, we have witnessed an exponential increase in the number of gender-affirming surgeries performed in the last 2 decades.
Of the affirming surgical spectrum, "bottom" genitourinary surgeries remain the most challenging.
Specifically, phalloplasty is a masculinizing surgery for neophallus creation using free tissue transfer from other parts of the body and microvascular techniques for nerve and vessel reattachment.
In radial forearm free flap (RFFF) phalloplasty, nerves from the forearm are harvested with the flap and sutured to nerves in the groin to provide postoperative sensation in the neophallus.
Despite transmasculine patients ranking sensation as one of their top priorities, standard nerve coaptations performed in phalloplasty fail to provide consistent sensation with scarce dedicated research aimed at enhancing neophallus sensory outcomes.
Without scientific advances, phalloplasty will remain far from perfect, negatively affecting patients' sexual health, causing dissatisfaction, and increasing the risk of surgical regret and persistent dysphoria.
Peripheral nerve regeneration remains the limiting factor for ideal sensory recovery due to the slow and inconsistent rates of regeneration, and the negative effects of axonal degeneration that occurs post-injury.
We advocate for using polyethylene glycol as a "fusogen" to achieve nerve fusion in peripheral nerve coaptations.
Polyethylene glycol (PEG) is a hydrophilic compound that enhances the fusion of the lipid bilayer membrane of severed axons, restoring the nerve's immediate ability to conduct electrical signals across the repair site.
Our group has conducted extensive mammalian and preliminary human studies using our novel PEG-fusion protocol for nerve coaptations.
In both ex-vivo and in-vivo studies in rats with severed sciatic nerves, PEG-assisted nerve coaptation restored morphological continuity and led to a remarkable early improvement in functional outcomes.
In the first human PEG fusion of injured digital nerves performed by our team, we saw rapid nerve recovery and early functional outcomes as early as one week.
Based on our experience with PEG fusion, we will be conducting a randomized clinical trial to test the efficacy of PEG-assisted nerve coaptation in achieving superior neophallus sensory function following phalloplasty.
Sponsor: Vanderbilt University Medical Center
Current Primary Outcome: measures sensory recovery
Original Primary Outcome: measures sensory recovery
Current Secondary Outcome:
Original Secondary Outcome:
Information By: Vanderbilt University Medical Center
Dates:
Date Received: June 01, 2023
Date Started: 2023-06-03
Date Completion: {'date': '2023-06-03', 'type': 'ESTIMATED'}
Last Updated: 2023-06-01
Last Verified: 2023-06
