Clinical Trial: KL-6 Protein as a Biomarker of Lung Injury in Viral Bronchiolitis

Study Status: Completed
Recruit Status: Unknown status
Study Type: Observational

Official Title: Acute Bronchiolitis in Infants: Analysis of a Biomarker of Epithelial Lung Injury - Clinical and Virological Correlation

Brief Summary: Serum KL-6 protein has been described as a biomarker of epithelial lung injury in Respiratory Syncytial Virus bronchiolitis. The investigators can imagine that epithelial injury intensity has consequences on immediate and later respiratory prognosis. Furthermore, this prognosis seems to be different according to the respiratory causative virus. The investigators propose to study, during an epidemic season, the correlation between KL-6 levels and clinical severity, and the type of viral infection.

Detailed Summary: Prospective, monocentric, case-control and transversal study Primary end-point: correlation between serum KL-6 level and severity of the bronchiolitis, evaluated by a clinical scoring system established at the time of the admission in Paediatric Emergency Unit Secondary end-points: respiratory virus detected by EIA and RT-PCR, phylogenetic study of rhinovirus, length of hospitalisation, immediate morbidity and mortality, risk of asthma at the age of three years old.
Sponsor: University Hospital, Clermont-Ferrand

Current Primary Outcome: KL-6 rate [ Time Frame: At day 1 ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University Hospital, Clermont-Ferrand

Dates:
Date Received: September 12, 2011
Date Started: October 2011
Date Completion: October 2016
Last Updated: September 20, 2011
Last Verified: September 2011