Clinical Trial: Effects of Rhinopharyngeal Retrograde Clearance in Children With Acute Viral Bronchiolitis

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Comparison Between Rhinopharyngeal Retrograde Clearance and Nasopharyngeal Aspiration in Children With Acute Viral Bronchiolitis

Brief Summary: The purpose of this study is to compare the immediate effects of retrograde rhinopharyngeal clearance with nasopharyngeal aspiration in children admitted with acute viral bronchiolitis. The investigators selected children, up to 12 months old, admitted for acute viral bronchiolitis. Patients were divided in aspiration group (AG), submitted to nasopharyngeal aspiration, and clearance group (CG), submitted to retrograde rhinopharyngeal clearance with physiological solution (0.9%) instillation (RRC) technique. In both groups children were evaluated three times in the same day in order to verify cardiorespiratory parameters, clinical score of respiratory dysfunction and adverse effects.

Detailed Summary: Children up to 12 months old, admitted for acute viral acute viral bronchiolitis were selected. All children participating in the study should be in the first 48 hours of hospitalization. Patients were divided in aspiration group (AG), submitted to nasopharyngeal aspiration, and clearance group (CG), submitted to retrograde rhinopharyngeal clearance (RRC) technique with physiological solution (0.9%) instillation. In both groups children were evaluated three times in the same day (data collection 1 (C1) - performed early in the morning; data collecting 2 (C2) - performed in the early afternoon; and data collecting 3 (C3) - performed in the evening). In each data collection, cardiorespiratory parameters and clinical score of respiratory dysfunction were evaluated before procedures (T0), 10 minutes after (T1) and 30 minutes after (T2). Adverse effects were evaluated during the whole day of the study.
Sponsor: Pontificia Universidade Católica do Rio Grande do Sul

Current Primary Outcome:

  • Occurrence of chest retractions as a measure of respiratory distress [ Time Frame: 30 minutes ]
  • Occurrence of wheezing as a measure of respiratory distress [ Time Frame: 30 minutes ]
  • Number of nasal bleeding events as a measure of adverse effects [ Time Frame: 1 day ]
  • Number of vomit episodes as a measure of adverse effects [ Time Frame: 1 day ]


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Measurement of the heart rate using an oximeter [ Time Frame: 30 minutes ]
  • Measurement of the respiratory rate [ Time Frame: 30 minutes ]
  • Measurement of the oxygen saturation using an oximeter [ Time Frame: 30 minutes ]
  • Severity scores on the Wood clinical score [ Time Frame: 30 minutes ]


Original Secondary Outcome: Same as current

Information By: Pontificia Universidade Católica do Rio Grande do Sul

Dates:
Date Received: May 28, 2015
Date Started: March 2013
Date Completion:
Last Updated: June 2, 2015
Last Verified: June 2015