Clinical Trial: CPAP Application in the Treatment of Asthmatic Children

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Effects of Continuous and Bilevel Positive Airway Pressure During Exercise-induced Bronchoconstriction in Asthmatic Children: Controlled Clinical Trial, Randomized

Brief Summary:

Asthma is characterized by recurrent episodes of bronchospasm, bronchial hyperresponsiveness and chronic airway inflammation and pharmacological treatment for this condition is done with bronchodilators and anti-inflammatory. Pharmacologic therapy has clinical efficacy in the control, but the patient often does not adhere adequately.

There is need for further research into non-pharmacological therapies for clinical asthma control and in turn the use of CPAP and bilevel pressure in the airways has shown beneficial effects on autonomic modulation and bronchial responsiveness leading to the hypothesis that these therapies also have effects on the BIE.

The aim of this study is to evaluate the effect of these non-pharmacological therapies in several variables and especially the BIE.


Detailed Summary:
Sponsor: University of Nove de Julho

Current Primary Outcome: Exhaled nitric oxide (part per billion) [ Time Frame: 5 minutes ]

assess the degree of inflammation of the respiratory system using expired fraction of nitric oxide before and after the different protocols applied


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Heart Rate Variability [ Time Frame: 20 minutes ]
  • manovacuometry [ Time Frame: 10 minutes ]
  • Pulmonary function test [ Time Frame: 20 minutes ]
  • bioelectrical impedance [ Time Frame: 10 minutes ]
  • Bronchoconstriction induced by stress [ Time Frame: 30 minutes ]


Original Secondary Outcome: Same as current

Information By: University of Nove de Julho

Dates:
Date Received: October 12, 2016
Date Started: January 2015
Date Completion: December 2016
Last Updated: October 17, 2016
Last Verified: October 2016