Clinical Trial: Bronchospasm Associated With High Nitric Oxide

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Higher Exhaled Nitric Oxide (NO) is Associated With Intraoperative Bronchospasm

Brief Summary: Intraoperative bronchospasm challenges anesthesia's safety. This study aims to investigate high concentration of exhaled nitric oxide as a marker of intraoperative bronchospasm.

Detailed Summary: Previous studies in asthmatic patients suggested that exhaled nitric oxide may represent a noninvasive measure for airway inflammation. Anesthesia information forms from 1999 throughout 2004 were revised (n=146.358). Bronchospasm occurrence appeared registered on 863 forms. From those, nine were identified as non-asthmatics patients (Bronchospasm group). Also, 12 asthmatics constituted one additional group (Asthma group) and 10 subjects with no previous airway disease or symptoms (Control group). All subjects were submitted to Exhaled nitric oxide measurements (parts/billion), spirometry and induced sputum.
Sponsor: University of Sao Paulo

Current Primary Outcome: Exhaled nitric oxide in parts per billion [ Time Frame: one to six months after surgery ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Eosinophils concentration within sputum sample, pulmonary function tests [ Time Frame: one to six months after surgery ]

Original Secondary Outcome: Same as current

Information By: University of Sao Paulo

Dates:
Date Received: April 23, 2008
Date Started: January 1999
Date Completion:
Last Updated: April 23, 2008
Last Verified: April 2008