Clinical Trial: Brain fMRT In Takotsubo Cardiomyopathy

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Pilot Study: Central Nervous System and Hormonal Changes In Takotsubo Cardiomyopathy

Brief Summary:

Certain cardiac and neurologic diseases influence each other via a still poorly understood "brain-heart axis". Subarachnoidal bleedings are well known to cause ECG alterations resembling those of myocardial infarction, along with a reduction of systolic myocardial function ("neurogenic stunned myocardium"). Alterations of the right insula region by a stroke or intracranial hemorrhage go along with a sympathetic activation (increased circulating catecholamine levels, tachycardia, arterial hypertension). In contrast, alterations of the left insula region often cause vagal reactions such as bradycardia, arterial hypotension. Takotsubo cardiomyopathy (TTC) is a just recently recognised subform of heart attacks, often caused by psychological or physical stress (death of a beloved one, divorce, job loss, infection, preoperative state). In more than 90% of cases, TTC affects postmenopausal women.

Functional MRT enables imaging of activated brain regions, either without ("resting state") or with specific stimuli. The investigators speculate that there is a specific involvement of the insula region during TTC.

Detailed Summary:
Sponsor: Wolfgang Dichtl, MD PhD

Current Primary Outcome: Changes in brain functional MRT (resting state, paradigma) in postmenopausal females suffering from TTC as compared to NSTEMI / STEMI postmenopausal female patients [ Time Frame: Within the first 72h after diagnosis and after 4-8 weeks ]

Original Primary Outcome: Changes in brain functional MRT (resting state) in postmenopausal females suffering from TTC as compared to STEMI postmenopausal female patients [ Time Frame: Within the first 48h after diagnosis and after 4-8 weeks ]

Current Secondary Outcome:

Original Secondary Outcome: Changes in EEG in postmenopausal females suffering from TTC as compared to STEMI postmenopausal females [ Time Frame: Within the first 48 hours after diagnosis and after 4-8 weeks ]

Information By: Medical University Innsbruck

Dates:
Date Received: September 11, 2014
Date Started: October 2014
Date Completion: December 2018
Last Updated: September 29, 2016
Last Verified: September 2016