Clinical Trial: Blood and Cerebrospinal Fluid for Pediatric Brain Tumor Research

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Collection of Blood and Cerebrospinal Fluid for Pediatric Brain Tumor Research

Brief Summary: In normal patients, blood and cerebrospinal fluid (CSF) contain circulating cells and other molecules such as proteins and nucleic acids. In patients with central nervous system (CNS) and other conditions, the levels of these molecules may be altered. In several other studies at our institution, the investigators are investigating such molecules in tumor specimens as well as the blood and cerebrospinal fluid of pediatric patients with CNS tumors. However, these levels are difficult to interpret without comparing them to levels in patients without CNS tumors. The investigators propose a study to collect small amounts of blood and cerebrospinal fluid from pediatric patients without CNS tumors who are undergoing a diagnostic or therapeutic neurosurgical procedure aimed at addressing altered CSF dynamics.

Detailed Summary:
Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Current Primary Outcome: levels of miRNAs in the blood and CSF [ Time Frame: 2 yrs ]

Original Primary Outcome: Same as current

Current Secondary Outcome: Survivin and biologic markers levels in the CSF and blood [ Time Frame: 2 yrs ]

Original Secondary Outcome: Same as current

Information By: Ann & Robert H Lurie Children's Hospital of Chicago

Dates:
Date Received: February 24, 2012
Date Started: July 2011
Date Completion:
Last Updated: February 3, 2016
Last Verified: February 2016