Clinical Trial: MRI-based Neuroimaging Predictors of Clinical Improvements Following Therapy in Children With Cerebral Palsy

Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Observational

Official Title: MRI-based Neuroimaging Predictors of Clinical Improvements Following Occupational Therapy (OT) or OT Puls Acupuncture and Massage Methods in Children With Cerebral Palsy

Brief Summary: The aim of this study is to explore the relationship between brain MRI-metrics and hand function observed in children with cerebral palsy (CP),compared between baseline and the third month, and thus determine the early MRI-based neuroimaging predictor of clinical improvement following therapy in children with CP.

Detailed Summary:

Cerebral palsy (CP) is the commonest cause of neurological disability in children. The upper limbs are often affected, with significant hand involvement from an early age.There are various methods of treatment for CP children with hand function disability. However, there is a lack of effective methods to predict the prognosis.

This prospective cohort study will include children with occupational therapy (OT) or OT plus acupuncture and massage methods. Children with CP will be evaluated in terms of upper limb motor function using the manual ability classification system (MACS), fine motor function measure (FMFM). The Brain injuries of Children will be evaluated by MRI.

The aim of this study is to explore the relationship between brain MRI-metrics and hand function, compared between baseline and the third month, and thus determine the early MRI-based neuroimaging predictors of clinical improvements following therapy in children with CP.


Sponsor: First Affiliated Hospital Xi'an Jiaotong University

Current Primary Outcome:

  • Fine motor function measure (scores) [ Time Frame: Baseline ]
    It is acquired at baseline.
  • Fine motor function measure (scores) [ Time Frame: The 3rd month ]
    It is acquired at 3 months later following therapy.


Original Primary Outcome: Same as current

Current Secondary Outcome:

  • Gross motor function measure and classification system (scores) [ Time Frame: Baseline ]
    It is acquired at baseline.The system is a 5 level clinical classification system that describes the gross motor function of people with cerebral palsy on the basis of self-initiated movement abilities.
  • Gross motor function measure and classification system (scores) [ Time Frame: The 3rd month ]
    It is acquired at 3 months later following therapy.


Original Secondary Outcome: Same as current

Information By: First Affiliated Hospital Xi'an Jiaotong University

Dates:
Date Received: November 24, 2016
Date Started: December 2016
Date Completion: December 2019
Last Updated: December 4, 2016
Last Verified: November 2016