Clinical Trial: Cerebral Toxoplasmosis and AIDS
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: Cerebral Toxoplasmosis and AIDS in the French Departments of America (DFA). Diagnostic Contribution of a PCR Assay and Genetic Diversity of Toxoplasma Gondii.
Brief Summary:
With a HIV incidence much higher in the DFA than in European French territory, this disease is a major public health problem in these areas, especially in French Guiana.
Cerebral toxoplasmosis is a priority among the opportunistic infections in AIDS patients from the DFA because of its frequency (French West Indies) and of its lethality (French Guiana).
The diagnosis of cerebral toxoplasmosis may be difficult because based only on presumptive clinical and radiological features. The response to specific antitoxoplasmic therapy confirms a posteriori the diagnosis.
In reference to the data collected by the Biological Resource Centre Toxoplasma, in particular in French Guiana, we think that T. gondii strains reactivating in AIDS patients from DFA are genetically different from those reactivating in AIDS patients from Europe, with an increased capacity for dissemination via peripheral blood in the first ones. This more frequent or more prolonged parasitemia could facilitate the diagnosis of cerebral toxoplasmosis by PCR test from peripheral blood samples in AIDS patients from the French departments of America.
Detailed Summary:
Sponsor: University Hospital, Limoges
Current Primary Outcome:
Original Primary Outcome: To evaluate the diagnostic performance of the real-time PCR Toxoplasma assay from peripheral blood samples in cerebral toxoplasmosis in AIDS patients from the DFA.
Current Secondary Outcome: Isolation, genetic typing and storage of T. gondii strains collected among AIDS patients with cerebral toxoplasmosis from the DFA. [ Time Frame: 3 years ]
Original Secondary Outcome: Isolation, genetic typing and storage of T. gondii strains collected among AIDS patients with cerebral toxoplasmosis from the DFA.
Information By: University Hospital, Limoges
Dates:
Date Received: December 2, 2008
Date Started: June 2009
Date Completion:
Last Updated: March 22, 2014
Last Verified: December 2013
