Clinical Trial: Hypoalgesic Effect of Neural Mobilization Versus Ibuprofen Pharmacologic Treatment

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Hypoalgesic Effect of Median Nerve Neural Mobilization Versus Ibuprofen Pharmacologic Treatment in Patients With Cervicobrachial Pain

Brief Summary: The purpose of this study is to compare the effectivity of Median Nerve Neural Mobilization and oral Ibuprofen in treating patients who suffer cervicobrachial pain

Detailed Summary:

Median Nerve Neural Mobilization and Ibuprofen both relieve cervicobrachial pain, but this happens through different mechanisms and with a different onset of side effects. Median Nerve Neural Mobilization is a physical therapy technique that achieves pain relief through mechanical stimulation of the median nerve and the brachial plexus. The proper mechanical stimulation of the nerve and its surrounding neural tissue induces a wide variety of physiologic responses that may reduce cervicobrachial pain including the activation of descending nervous system pain modulation mechanisms, all though the entire set of underlying reasons for this pain reduction is not completely understood. Among the effects caused by the Neural Tissue Mobilization that produce pain relief are: intraneural edema reduction, changes on the intraneural nerve pressure,dispersion of pro-inflammatory substances and an increase in nerve mobility

Ibuprofen is a nonsteroidal anti-inflammatory drug used worldwide to control pain, fever and inflammation.Oral intake of Ibuprofen produces a hypoalgesic effect due to biochemical inhibition of the COX enzymes, which convert arachidonic acid to prostaglandin H2 (PGH2). PGH2, which in turn, is converted by other enzymes to several types of prostaglandins and thromboxanes (which are mediators of pain and inflammation).

Side effects derived from the oral intake of Ibuprofen are related to its systemic action and can be severe in some patients. This fact suggests that oral Ibuprofen may not be suitable to use in all types of patients suffering from cervicobrachial pain, meanwhile the Median Nerve Neural Mobilization has little to no side effects known. This reveals a point of interest in determining comparative effectiveness between this two therapeutic options in the treatment of cervicobrachial pain.


Sponsor: Universidad Europea de Madrid

Current Primary Outcome: Change from baseline using the Numeric Rating Scale for Pain at 1 hour [ Time Frame: at baseline and 1 hour after the application of treatment, corresponding to intervention sessions 1, 15 and 30 ]

The Numeric Rating Scale (NRS) is an 11 point scale for patient self-reporting of pain, it was employed to evaluate the presence and relieve of cervicobrachial pain symptoms


Original Primary Outcome: Change from baseline using the Numeric Rating Scale for Pain at 1 hour [ Time Frame: at baseline and 1 hour after the application of treatment, corresponding to intervention sessions 1, 9 and 18 ]

The Numeric Rating Scale (NRS) is an 11 point scale for patient self-reporting of pain, it was employed to evaluate the presence and relieve of cervicobrachial pain symptoms


Current Secondary Outcome:

  • Change from baseline of the Physical function involving the affected upper limb using the Quik DASH Scale [ Time Frame: at baseline, corresponding to intervention session 1 and 30 of treatment. ]
    The Disabilities of the Arm, Shoulder and Hand ( QuickDASH) Test is a self-report short questionnaire designed to measure physical function and symptoms in people with any of several musculoskeletal disorders of the upper limb.
  • Change from baseline cervical rotation range of motion at 1 hour [ Time Frame: at baseline and 1 hour after the application of treatment, corresponding to intervention sessions 1 and 30 ]
    Cervical rotation was assessed in units of rotation degrees, using the cervical range-of-motion device (CROM).


Original Secondary Outcome:

  • Change from baseline of the Physical function involving the affected upper limb using the Quik DASH Scale [ Time Frame: at baseline, corresponding to intervention session 1 and 18 of treatment. ]
    The Disabilities of the Arm, Shoulder and Hand ( QuickDASH) Test is a self-report short questionnaire designed to measure physical function and symptoms in people with any of several musculoskeletal disorders of the upper limb.
  • Change from baseline cervical rotation range of motion at 1 hour [ Time Frame: at baseline and 1 hour after the application of treatment, corresponding to intervention sessions 1, 9 and 18 ]
    Cervical rotation was assessed in units of rotation degrees, using the cervical range-of-motion device (CROM).


Information By: Universidad Europea de Madrid

Dates:
Date Received: October 26, 2015
Date Started: July 2015
Date Completion:
Last Updated: January 1, 2017
Last Verified: January 2017