Clinical Trial: Treatment of Survivors After Botulism Outbreak

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: An Outbreak of Botulism in Thailand: Clinical Manifestations and Management of Severe Respiratory Failure

Brief Summary:

Background. Northern Thailand's biggest botulism outbreak to date occurred on 14 March 2006 and affected 209 people. Of these, 42 developed respiratory failure, and 25 of those who developed respiratory failure were referred to 9 high facility hospitals for treatment of severe respiratory failure and autonomic nervous system involvement. Among these patients, we aimed to assess the relationship between the rate of ventilator dependence and the occurrence of treatment by day 4 versus day 6 after exposure to bamboo shoots (the source of the botulism outbreak), as well as the relationship between ventilator dependence and negative inspiratory pressure.

Methods. The investigators reviewed the circumstances and timing of symptoms following exposure. Mobile teams treated patients with botulinum antitoxin on day 4 or day 6 after exposure in Nan Hospital (Nan, Thailand). Eighteen patients (in 7 high facility hospitals) with severe respiratory failure received a low- and high-rate repetitive nerve stimulation test, and negative inspiratory pressure was measured.

Detailed Summary:
Sponsor: Rajavithi Hospital

Current Primary Outcome:

Original Primary Outcome:

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Rajavithi Hospital

Dates:
Date Received: March 30, 2006
Date Started: March 2006
Date Completion: April 2006
Last Updated: October 23, 2008
Last Verified: August 2007