Clinical Trial: Effect of Fasting Versus Feeding on the Bone Metabolic Response to Running

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: Effect of Fasting Versus Feeding on the Bone Metabolic Response to Running

Brief Summary: This study examined changes in bone metabolism (markers of bone turnover, calcium metabolism) with a bout of acute treadmill running preceded by either a single, mixed meal or an overnight fast.

Detailed Summary: Ten physically active males aged 28 ± 4 y (mean ± 1SD) completed two, counterbalanced, 8 d trials. After 3 d on a standardised diet, participants performed 60 min of treadmill running at 65% VO2max on Day 4 following an overnight fast (FAST) or a standardised breakfast (FED). Blood samples were collected at baseline, before exercise, during exercise, for 3h after exercise and on four consecutive follow-up days (FU1-FU4). Plasma/serum were analysed for β CTX, P1NP, OC, bone ALP, PTH, ACa, PO4, OPG, cortisol, leptin and ghrelin.
Sponsor: QinetiQ Ltd

Current Primary Outcome: Change in C-terminal telopeptide region of collagen type 1 (B-CTX) concentration from baseline [ Time Frame: At 08:00 h (Baseline), 09:00 h, 09:30 h, and 10:15 h (Pre-exercise), after 30 and 60 min of exercise, after 1, 2, and 3 h of recovery and at 1, 2, 3 and 4 day post-exercise ]

B-CTX is a specific marker of bone resorption. It's circulating concentration is altered by both exercise and feeding


Original Primary Outcome: Same as current

Current Secondary Outcome: Change in parathyroid hormone (PTH) concentration from baseline [ Time Frame: At 08:00 h (Baseline), 09:00 h, 09:30 h, and 10:15 h (Pre-exercise), after 30 and 60 min of exercise, after 1, 2, and 3 h of recovery and at 1, 2, 3 and 4 day post-exercise ]

PTH is reported to induce both bone resorption and bone formation. It's circulating concentration is altered by both exercise and feeding.


Original Secondary Outcome: Same as current

Information By: QinetiQ Ltd

Dates:
Date Received: January 4, 2012
Date Started: July 2007
Date Completion:
Last Updated: January 4, 2012
Last Verified: January 2012