Clinical Trial: The Efficacy of Velcade on Bone Tissue During Myelomatosis (Bone Marrow Cancer)

Study Status: Completed
Recruit Status: Completed
Study Type: Interventional

Official Title: The Efficacy of Velcade on Bone Tissue During Myelomatosis (Bone Marrow Cancer)

Brief Summary: The primary objective of the the study is to investigate the changes in bone remodeling during Velcade treatment.

Detailed Summary:

20 patients will be included in the study over a 2 year period. Before, during and after treatment we will measure NTX-I, CTX-I, CTX-MMP, bALP, DKK-1, PINP, TRAcP and PTH. NTX, CTX and CTX-MMP are measured to estimate bone degradation. TRAcP is measured to estimate the activity of the osteoclasts. bALP and DKK-1 is measured to evaluate the activity of the osteoblasts and PINP is measured as a marker of new bone formation. PTH is measured in order to evaluate if the positive effects that is observed in bone formation in relations to velcade treatment is due to the pulsative way velcade is administered.

The effect of the velcade treatment will be evaluated by x-ray, bone marrow and m-component.

Sponsor: Vejle Hospital

Current Primary Outcome: Changes in bone markers during treatment

Original Primary Outcome: Same as current

Current Secondary Outcome: Changes in osteolysis during treatment

Original Secondary Outcome: Same as current

Information By: Vejle Hospital

Dates:
Date Received: February 15, 2007
Date Started: February 2007
Date Completion:
Last Updated: July 7, 2009
Last Verified: July 2009