Clinical Trial: Effect of Equal Ratio Ventilation on Blood Loss During Posterior Lumbar Interbody Fusion Surgery

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Interventional

Official Title: Effect of Equal Ratio Ventilation on Blood Loss During Posterior Lumbar Interbody Fusion Surgery: A Randomized Controlled Trial

Brief Summary: Ventilator mode change was associated with decrease in blood loss during posterior lumbar interbody fusion (PLIF) due to decrease in the peak inspiratory pressure (PIP). The purpose of this study was to determine the effect of equal ratio ventilation (ERV), which sets the I:E ratio of the ventilator to 1:1 during volume controlled ventilaiton, on surgical blood loss during PLIF. Investigators hypothesized that ERV would decrease surgical blood loss due to decrease in the PIP.

Detailed Summary: After anesthesia, patients will receive ventilator settings according to theri group. The CVP will be measured before and after the prone position to ensure the proper positioning. Airway pressures including peak inspiratory pressure, mean/plateau airway pressure, arterial blood gas analysis data, hct, lactate, body temperature, mean arterial pressure, cardiac index. Recodings will be done 5min afte the induction, 5 min after the prone positioning, sikin suture, and 5min after supine position. Amount of bleeding, coagulation profile and Hct will be recorded 72 hrs after the surgery.
Sponsor: Gangnam Severance Hospital

Current Primary Outcome: The amount of intraoperative surgical bleeding [ Time Frame: At the end of the surgery, approximately 4 hrs. ]

Original Primary Outcome: The amount of intraoperative surgical bleeding [ Time Frame: At the end of the surgery ]

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Gangnam Severance Hospital

Dates:
Date Received: January 22, 2017
Date Started: March 6, 2017
Date Completion: December 2017
Last Updated: March 6, 2017
Last Verified: March 2017