Clinical Trial: Alcohol Consumption With or Without a Multispecies Probiotic
Study Status: Not yet recruiting
Recruit Status: Not yet recruiting
Study Type: Interventional
Official Title: Effect of Alcohol Consumption With or Without a Multispecies Probiotic on Gut Permeability, Bacterial Translocation Neutrophil Function and Hangover Symptoms
Brief Summary:
Alcohol leads to a leaky gut and translocation of bacterial products. This may lead to inflammation and immune dysfunction as well as the typical hangover symptoms. Probiotics are able to restore gut permeability and decrease bacterial translocation. A multispecies probiotic may be able to restore gut permeability and decrease bacterial translocation as well as inflammation, immune dysfunction and hangover symptoms after alcohol consumption.
Specifically, gut permeability, bacterial translocation, inflammation, immune dysfunction and hangover symptoms in patients after alcohol ingestion +/- ingestion of a multispecies probiotic
Detailed Summary:
Alcohol binge drinking, defined as 5 or more drinks for men and 4 or more drinks for women at one time, is the most frequent form of alcohol consumption worldwide, especially in younger people. This drinking pattern is popular and leads to increased mortality and morbidity. Therefore binge drinking is a major public health issue. The behavioural and neurological consequences of binge drinking are well characterized.
Less is known about the systemic effects on the gut as the first organ in contact with alcohol. Chronic alcohol intake can lead to increased gut permeability, bacterial translocation and alterations in the gut microbiome in animal models. Recently bacterial translocation has been shown in healthy volunteers after a single alcohol binge. On immune cells, acute alcohol intake seems to have dichotomous effects. On the one hand immunosuppressive and anti-inflammatory effects have been described, however, alcohol induced liver injury is driven by pro-inflammatory reactions. These immune effects seem to be driven by endotoxin or other bacterial products via Toll-like receptors that are translocated to the circulation via a defective gut barrier. Immune effects of alcohol have also been linked to hangover symptoms after an alcohol binge.
Furthermore there is evidence that endotoxemia might also contributes to alcohol dependence by promoting prolonged and increased voluntary alcohol intake in mice. On the other hand mutant mice lacking important genes for immune responses exhibit decreased alcohol consumption. This indicates that immune signaling promotes alcohol consumption. Therefore it is tempting to speculate that increased gut permeability leading to increased bacterial translocation after an acute alcohol binge could promote the desire for further alcohol consumption.
Same as current
Current Secondary Outcome:
- gut permeability (zonulin in stool) [ Time Frame: 4 hours ]changes in gut permeability
- bacterial translocation (bacterial DNA in serum) [ Time Frame: 4 hours ]changes in bacterial translocation
- oxidative stress (advanced oxidation protein products) [ Time Frame: 4 hours ]changes in oxidative stress
- inflammation (neutrophil oxidative burst) [ Time Frame: 4 hours ]changes in inflammation
- neutrophil phagocytic capacity [ Time Frame: 4 hours ]changes in neutrophil function
- gut microbiome composition [ Time Frame: 4 hours ]changes in gut microbiome composition
Original Secondary Outcome: Same as current
Information By: Medical University of Graz
Dates:
Date Received: July 29, 2015
Date Started: December 2016
Date Completion: January 2018
Last Updated: November 29, 2016
Last Verified: November 2016
