Clinical Trial: Bartonella in Liver Transplant Patients

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Undetected Bartonella Spp. Infection Puts Liver Transplant Patients at Great Risk

Brief Summary: Approximately 20 volunteers who have received a liver transplant and have been diagnosed with cryptogenic cirrhosis will be included in this study. Blood, skin and urine samples will be analyzed for Bartonella spp..

Detailed Summary: Approximately 20 volunteers who have received a liver transplant and have been diagnosed with cryptogenic cirrhosis will be included in this study. Blood samples will be analyzed for Bartonella using the state-of-the art Bartonella Alpha Proteobacterium Growth Medium (BAPGM) multi-platform testing, including liquid culture, enriched agar plating and molecular techniques. Blood smears will be analyzed for intra-erythrocytic Bartonella spp. Four-millimeter skin biopsies from non-lesional skin will be acquired from the same patients, processed using our published techniques, and imaged using confocal microscopy and compared to BAPGM test results. additionally, urine samples will be collected and analyzed for microRNAs.
Sponsor: University of Minnesota - Clinical and Translational Science Institute

Current Primary Outcome: Liver transplant subject that show evidence of Bartonella DNA and Bartonella antibodies using the Alpha Proteobacterium Growth Medium (BAPGM) [ Time Frame: 90 weeks ]

Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University of Minnesota - Clinical and Translational Science Institute

Dates:
Date Received: October 19, 2015
Date Started: December 2013
Date Completion: December 2018
Last Updated: January 25, 2017
Last Verified: January 2017