Clinical Trial: Influence of Acid Reflux on Stromal Epithelial Interaction in Barrett's Esophagus

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Influence of Acid Reflux on Stromal Epithelial Interaction in Barrett's Esophagus

Brief Summary:

The purpose of this study is to determine the association between acid reflux and cell changes in Barrett's esophagus.

Specific aim 1: To test the hypothesis that controlled acid reflux is associated with lesser degree of stromal activation.

Specific aim 2: To test the hypothesis that stromal fibroblast derived growth factors drive BE epithelial proliferation.


Detailed Summary:
Sponsor: Mayo Clinic

Current Primary Outcome: activated myofibroblasts [ Time Frame: 6 months ]

The primary end point for the study will be the proportion of patients with activated myofibroblasts (defined as positive staining for SMA and vimentin with negative staining for Desmin, in > 50% of subepithelial myofibroblasts). This primary end point will be compared between the group with controlled acid reflux and the group without acid reflux.


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Mayo Clinic

Dates:
Date Received: January 20, 2011
Date Started: October 2008
Date Completion:
Last Updated: May 3, 2013
Last Verified: May 2013