Clinical Trial: BETERNet Notch Signaling and Novel Biomarkers for Barretts Esophagus

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Notch Signaling and Novel Biomarkers for Barretts Esophagus

Brief Summary: This research study hopes to identify new molecular markers in the tissue of Barrett's esophagus that will help physicians better understand and manage this condition. Patients undergoing an upper endoscopy will be asked to complete a gastroesophageal reflux disease (GERD) questionnaire, provide a blood sample and allow additional biopsies to be taken during the procedure.

Detailed Summary: This research study hopes to identify new molecular markers in the tissue of Barrett's esophagus that will help physicians better understand and manage this condition. Currently there is very little understanding as to how Barrett's esophagus develops and why some people with Barrett's esophagus go on to develop esophageal cancer. The purpose of this study is to develop a better understanding of how these processes occur. The investigators also hope to use the information from this study to identify new molecular markers that the investigators can use to better determine who will or will not go on to develop esophageal cancer. Patients who have been diagnosed in the past with Barrett's esophagus will be asked to participate. Patients without Barrett's esophagus will be asked to take part so that the investigators can compare tissue from patients without the conditions to those with the conditions.
Sponsor: Abramson Cancer Center of the University of Pennsylvania

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Information By: Abramson Cancer Center of the University of Pennsylvania

Dates:
Date Received: December 1, 2011
Date Started: November 2011
Date Completion:
Last Updated: January 24, 2017
Last Verified: January 2017