Clinical Trial: Neuromarker S-100B as Diagnostic Tool

Study Status: Completed
Recruit Status: Completed
Study Type: Observational

Official Title: Elevated Levels of S-100B and Neuron-specific Enolase (NSE) in Spine Surgery: A Comparison of Serum Levels With Surgery for Long-bone Fractures

Brief Summary: The hypothesis of this study is to find evidence if there is an influence of spine surgery on the serum levels of two proteins secreted from neuronal cells.

Detailed Summary: The question, if there is an effect on the cerebrospinal system during spine surgery, which can be traced by monitoring serum levels of neuromarkers is not yet answered. This study has its background from other studies on patients with traumatic brain injury (TBI), in whom elevated serum levels of the two neuromarkers S-100B and NSE are associated with injury severity, neuronal damage, brain, tissue damage, and outcome. Patients undergoing spine surgery with or without pre-existing traumatic neurologic symptoms are planned to be the study cohort. Pre- and postoperatively the serum levels of S-100B and NSE are obtained and are statistically compared with patients undergoing other types of bone-related surgery.
Sponsor: Medical University of Vienna

Current Primary Outcome: S-100B levels [ Time Frame: 4 hours ]

average timeframe between blood withdrawal (twice, pre-and post-operatively)


Original Primary Outcome: Same as current

Current Secondary Outcome:

Original Secondary Outcome:

Information By: Medical University of Vienna

Dates:
Date Received: April 23, 2013
Date Started: March 2013
Date Completion:
Last Updated: November 20, 2013
Last Verified: November 2013