Clinical Trial: MRI-changes in Morphometry and Cerebro Spinale Fluid (CSF) Flow in Spinal Cord Disorders

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title:

Brief Summary: Understanding the onset and progression of spinal cord disorders is an important aim in clinical neurology. An early diagnosis with consequent therapy might prevent the progression of disability. Therefore, we aim to determine structural and dynamic changes in the microstructure of the spinal cord and CSF, and to explore the relationships between the MRI parameters, clinical disability, and electrophysiology.

Detailed Summary:
Sponsor: University of Zurich

Current Primary Outcome: Morphometric changes and changes in cerebro spinal fluid (CSF) flow and spinal cord movement in patients and control subjects will be correlated to functional deficits and neurophysiological data (regression model analysis). [ Time Frame: Each subject will undergo 1 Scan of 1 hours and within two weeks of the scan they will undergo a 2 hours clinical examinations. ]

Original Primary Outcome: At cervical level C2 we will measure cross-sectional cord area (mm^2) [ Time Frame: Each subject will undergo 1 Scan of 1 hours and within two weeks of the scan they will undergo a 2 hours clinical examinations. ]

Current Secondary Outcome:

Original Secondary Outcome:

Information By: University of Zurich

Dates:
Date Received: June 5, 2014
Date Started: December 2012
Date Completion: December 2020
Last Updated: May 22, 2017
Last Verified: May 2017