Clinical Trial: Tumor and Development (TED)

Study Status: Recruiting
Recruit Status: Recruiting
Study Type: Observational

Official Title: Identification of Patients/Families With a Paediatric Tumor and One or More Developmental Abnormalities - Characterization of New Tumor Predisposition Syndromes and Study

Brief Summary: The overall project goal is to build a database of childhood cancers associated with developmental anomalies; it aims at identifying new syndromes of genetic predisposition and at enabling the further study of their molecular basis.

Detailed Summary:

Most of the solid cancers arising in the childhood develop from embryonic tissues. The frequent association of paediatric cancers and abnormalities of the development underlines the link between oncogenesis and embryogenesis. However, beside the known malformative syndromes predisposing to one or several types of tumours with a variable penetrance (NF1, Wiedemann-Beckwith, Denys-Drash, Fanconi disease), associations between abnormalities of the development and tumours are badly known and little investigated, and are not listed at present systematically in the registers of child cancers.

The cytogenetic exploration of malformative syndromes associated to tumours historically allowed to describe constitutional chromosomal abnormalities of major interest for the understanding of oncogenesis pathways of the most frequent sporadic tumours (del 11p13 and WT1; del 13q14 and Rb1). So, a rare and even exceptional clinical presentation can enrich the knowledge of a common pathology. Our objective is to analyze in a detailed and multidisciplinary way the largest number of possible cases of unusual presentation associating pediatric Tumor And abnormality of Development (TAD).

Principle objective

  • Registration of developmental abnormalities in pediatric patients with cancer retrospectively and prospectively for a period of three years on a nationwide scale Secondary objectives
  • to record tumoral pathologies in known contexts of cancer predisposition,
  • to record tumoral pathologies occurring in association with one or more developmental anomaly, these associations might have been already described or not
  • to identify and locate the biological samples of pat
    Sponsor: Assistance Publique - Hôpitaux de Paris

    Current Primary Outcome: Registration of developmental abnormalities in pediatric patients with cancer retrospectively and prospectively for a period of three years on a nationwide scale [ Time Frame: Day 0 ]

    Original Primary Outcome: Same as current

    Current Secondary Outcome:

    • to record tumoral pathologies in known contexts of cancer predisposition [ Time Frame: Day 0 ]
    • to record tumoral pathologies occurring in association with one or more developmental anomaly, these associations might have been already described or not [ Time Frame: Day 0 ]


    Original Secondary Outcome: Same as current

    Information By: Assistance Publique - Hôpitaux de Paris

    Dates:
    Date Received: August 2, 2013
    Date Started: June 2013
    Date Completion: June 2017
    Last Updated: August 25, 2016
    Last Verified: August 2016