Clinical Trial: Fertilizations With Immotile Sperm: Pentoxyphylline Activation Alone, or With Chemical Oocyte Activation
Study Status: Withdrawn
Recruit Status: Withdrawn
Study Type: Interventional
Official Title: A Randomized Controlled Trial to Compare Fertilizations With Immotile Sperm After Pentoxyphylline Activation Alone, or With Chemical Oocyte Activation
Brief Summary: Immotile sperm is a rather frequent problem encountered in IVF patients. Treatment is usually based on inducing motility with pentoxyphylline (PXN) followed by ICSI. However, fertilization rate with this method is still lower compared with ICSI using motile sperm. One of the reasons for that is the immotile sperm inability to activate the oocyte Our research hypothesis is that better fertilization rate can be accomplished in these cases by combining PXN sperm activation with Ca ionophore oocyte activation.
Detailed Summary:
Sponsor: Rambam Health Care Campus
Current Primary Outcome: Clinical pregnancy [ Time Frame: One month post oocyte retrieval ]
Original Primary Outcome: Same as current
Current Secondary Outcome: Fertilization rate [ Time Frame: One day post oocyte retrieval ]
Original Secondary Outcome: Same as current
Information By: Rambam Health Care Campus
Dates:
Date Received: January 29, 2014
Date Started: March 2014
Date Completion:
Last Updated: May 5, 2015
Last Verified: May 2015