Clinical Trial: Characteristics of Idiopathic Familial Speech Disorders
Study Status: Completed
Recruit Status: Completed
Study Type: Observational
Official Title: Characteristics of Idiopathic Familial Speech Disorders
Brief Summary:
According to studies, speech disorders with unknown causes (idiopathic) affect approximately 5% of the population at some point in their life. Some of these disorders like, stuttering and cluttering, are known for being detected early, during speech development.
Stuttering is characterized by sound and syllable repetitions and consonant/vowel prolongations. When stuttering is moderate to severe, it can interfere with a person's job and social activities.
Speech articulation disorders are characterized by omissions, or substitutions of speech sounds. The speech of a person who clutters is often difficult to understand. People are often unaware of the errors they make when speaking causing treatment of the condition to be very difficult.
The purpose of this research is to study an extended family whose members exhibit a pure form of speech articulation disorders
In addition, the study will use data and information gathered from the study and use it to develop guidelines (criteria) for defining and differentiating patients with speech disorders.
Detailed Summary:
Objective:
Our objective is to determine which factors are involved in the development of stuttering and familial phonological processing disorder and are associated with a familial pattern of inheritance.
Study population: The study population is comprised of 8 groups:
- Children and adults with persistent developmental stuttering;
- Unaffected siblings of the individuals affected with developmental stuttering or recovered from stuttering
- Children and adults who have recovered from developmental stuttering;
- Children and adults with persistent familial phonological processing disorders (FPPD);
- Unaffected siblings of the individuals affected with FPPD or have recovered from FPPD
- Children and adults who have recovered from FPPD;
- Unaffected siblings of the individuals who have recovered from FPPD;
- Children and adults with normal speech and language development who will comprise the control groups.
Design: A Natural history design will be used to compare affected and unaffected family members with healthy volunteers with normal speech and language.
Outcome Measures: Genetic markers and pedigree analyses will be used to test familial inheritance patterns. Speech and language development will be compared using indices of speech perception, auditory perception, self monitoring of one's own speech, language complexity, motor complexity, speech learning, phonological processing and verbal/nonverbal memory.
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
Current Primary Outcome:
Original Primary Outcome:
Current Secondary Outcome:
Original Secondary Outcome:
Information By: National Institutes of Health Clinical Center (CC)
Dates:
Date Received: November 3, 1999
Date Started: May 22, 1996
Date Completion:
Last Updated: January 24, 2017
Last Verified: November 13, 2009
